千亿体育

醫(yi)學(xue)(xue)(xue)部坐倚珞珈山,環繞東湖水,綠樹成蔭,花香流溢。學(xue)(xue)(xue)部源于1943年成立的湖北省省立醫(yi)學(xue)(xue)(xue)院(yuan),現在是武(wu)漢大學(xue)(xue)(xue)六大學(xue)(xue)(xue)部之(zhi)一。 學(xue)(xue)(xue)部含基礎醫(yi)學(xue)(xue)(xue)院(yuan)、第(di)一臨床學(xue)(xue)(xue)院(yuan)、第(di)二臨床學(xue)(xue)(xue)院(yuan)、口(kou)腔醫(yi)學(xue)(xue)(xue)院(yuan)、藥學(xue)(xue)(xue)院(yuan)、健康學(xue)(xue)(xue)院(yuan)、職業技術學(xue)(xue)(xue)院(yuan)...

地址: 湖北省武漢市武昌區東湖路115號
電話: 027-68759364
中國科學院院士: 鄧子新(xin)舒紅兵
國家級教學名師: 樊明文邊專
國家杰出青年基金獲得者: 鄧子新舒紅兵章曉聯李紅(hong)良(liang)卿國良
百千萬人才工程選者: 舒(shu)紅兵、黃從新章曉聯?
萬人計劃: 領軍人才: 舒(shu)紅(hong)兵(bing)唐其柱李紅良(liang) ? ? ?
教育部新世紀優秀人才: 章曉聯、何小(xiao)華樂江、 于紅剛 李(li)雁鄭芳、
胡錦躍、 黃(huang)鶴、李紅(hong)良、 張 旗、 葉曉(xiao)茜、 尚政(zheng)軍、 郭繼華、 張玉峰(feng)、
周海兵、 劉天罡、 王連(lian)榮(rong)、 瞿旭東、洪 葵(kui)

姓名: 鄧子新

單位: 武漢大學藥學院

職稱: 院士、院長

郵箱: zxdeng@habitsandgoals.com

聯系電話:

研究方向:

1.微生物藥物的合成途徑、代謝工程及合成生物學,DNA硫修飾的遺傳、生理及生化研究









代表性論著:

1. Xu T, Yao F, Zhou X, Deng Z, You D (2010). A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella. Nucleic Acids Research. Jul 12. [Epub ahead of print].

2. Shao Y, He X, Harrison EM, Tai C, Ou HY, Rajakumar K, Deng Z (2010). mGenomeSubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. Nucleic Acids Research. Sup:W194-200.

3. Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z (2010). Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. Journal of Biological Chemistry. 25;285(26):20097-108.

4. Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z. (2009) Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H. Journal of Biological Chemistry.17;284(16):10627-38.

5. Liu T, Cane DE, Deng Z. (2009) The enzymology of polyether biosynthesis. Methods in Enzymology, 459:187-214.

6. Xu H, Zhang Y, Yang J, Mahmud T, Bai L, Deng Z. (2009) Alternative Epimerization in C(7)N-Aminocyclitol Biosynthesis Is Catalyzed by ValD, A Large Protein of the Vicinal Oxygen Chelate Superfamily. Chemistry & Biology, 16(5):567-76.

7. Zhou Y, Li J, Zhu J, Chen S, Bai L, Zhou X, Wu H, Deng Z. (2008) Incomplete beta-Ketone Processing as a Mechanism for Polyene Structural Variation in the FR-008/Candicidin Complex. Chemistry & Biology,15(6):629-38.

8. Liu T, Lin X, Zhou X, Deng Z, Cane DE. (2008) Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chemistry & Biology, 15(5):449-58.

9. Zhao P, Bai L, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y, Deng Z, Floss HG. (2008) Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chemistry & Biology. 15(8):863-74

10. L. Wang, S. Chen, T. Xu, K. Taghizadeh, J. S. Wishnok, X. Zhou, D. You, Z. Deng*, Peter C. Dedon* (2007), Phosphorothioation of DNA in bacteria by dnd gene clusters, Nature Chemical Biology, 3(11):709-710. (Featured by “News & Views” written by Fritz Eckstein, Nature Chem. Biol. 3(11): 689-690, and by ACS “C&E News” Written by Carmen Drahl).

11. X. He, H. Ou, Q. Yu, X. Zhou, J. Wu, J. Liang, W. Zhang, K. Rajakumar, and Z. Deng (2007). Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria, Molecular Microbiology, 65(4):1034-48.

12. H. Ou, X. He, E. Harrison, B. Kulasekara, A. Thani, A. Kadioglu, S. Lory, J. Hinton, M. Barer, Z. Deng (2007): MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands, Nucleic Acids Research. 5: W97-W104..

13. J. Liang, Z. Wang, X. He, J. Li, X. Zhou, and Z. Deng (2007). DNA modification by sulphur: analysis of the sequence recognition specificity surrounding the modification sites. Nucleic Acids Research. 35(9):2944-54.

14. T Liu, D You, C Valenzano, Y Sun, J Li, Q Yu, X Zhou, D. Cane, Z Deng (2006): Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis, Chemistry & Biology, 13(9):945-55.

15. L Bai, L Li, H Xu, K Minagawa, Y Yu, Y Zhang, X Zhou, H G. Floss, T Mahmud, and Z Deng (2006): Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A, Chemistry & Biology, 13, 387-397. (Highlighted in Nature Biotechnology 24 (6): 665, 2006)。

16. T Liu, D You, C Valenzano, Y Sun, J Li, Q Yu, X Zhou, D. Cane, Z Deng (2006): Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis, Chemistry & Biology, 13(9):945-55.

17. L Bai, L Li, H Xu, K Minagawa, Y Yu, Y Zhang, X Zhou, H G. Floss, T Mahmud, and Z Deng (2006): Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A, Chemistry & Biology, 13, 387-397. (Highlighted in Nature Biotechnology 24 (6): 665, 2006)。

18. Z. Deng and L. Bai (2006), Antibiotic biosynthetic pathways and pathway engineering--A growing research field in China, Natural Product Reports,23, 811 - 827.

19. X. Zhou, X. He, J. Liang., T. Xu, A. Li, T. Kieser, J. D. Helmann and Z. Deng (2005): A novel DNA modification by sulphur, Molecular Microbiology, 57(5): 1428-20. D. Zhu, X. He, X. Zhou, and Z. Deng (2005): Expression of the melC operon in several Streptomyces strains is positively regulated by AdpA, an AraC family transcriptional regulator involved in morphological development in Streptomyces coelicolor, Journal of Bacteriology, 187(9): 3180-3187.

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千亿体育