千亿体育

醫學(xue)(xue)(xue)部(bu)(bu)坐(zuo)倚珞珈山,環(huan)繞(rao)東湖水,綠樹成蔭,花香流溢。學(xue)(xue)(xue)部(bu)(bu)源于(yu)1943年成立的湖北省省立醫學(xue)(xue)(xue)院(yuan),現在是武(wu)漢大(da)(da)學(xue)(xue)(xue)六大(da)(da)學(xue)(xue)(xue)部(bu)(bu)之一(yi)。 學(xue)(xue)(xue)部(bu)(bu)含基礎(chu)醫學(xue)(xue)(xue)院(yuan)、第一(yi)臨(lin)床學(xue)(xue)(xue)院(yuan)、第二臨(lin)床學(xue)(xue)(xue)院(yuan)、口腔(qiang)醫學(xue)(xue)(xue)院(yuan)、藥學(xue)(xue)(xue)院(yuan)、健康(kang)學(xue)(xue)(xue)院(yuan)、職業技術學(xue)(xue)(xue)院(yuan)...

地址: 湖北省武漢市武昌區東湖路115號
電話: 027-68759364
中國科學院院士: 鄧子新(xin)舒紅兵(bing)
國家級教學名師: 樊明(ming)文(wen)邊(bian)專
國家杰出青年基金獲得者: 鄧子新舒紅兵章曉聯李紅良卿國良
百千萬人才工程選者: 舒紅兵、黃從新章曉聯?
萬人計劃: 領軍人才: 舒(shu)紅兵唐其柱李(li)紅良 ? ? ?
教育部新世紀優秀人才: 章曉聯、何(he)小華樂江(jiang)、 于紅剛 李雁鄭芳、
胡錦躍、 黃鶴、李(li)紅良、 張 旗、 葉(xie)曉茜、 尚政軍(jun)、 郭繼華(hua)、 張玉峰、
周海兵、 劉天罡(gang)、 王連榮、 瞿(ju)旭東、洪 葵(kui)

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姓名: 章曉(xiao)聯

單位(wei): 千億體(ti)育基(ji)礎醫(yi)學(xue)院免疫學(xue)系,湖北(bei)省過敏(min)及免疫相關(guan)疾病重點實驗室

職稱: 系主任(ren)及重點實驗室主任(ren)、教授、博導

郵(you)箱: zhangxiaolian@habitsandgoals.com

聯系(xi)電話: 027-68750067

研究方(fang)向:

1.糖基化修(xiu)飾(shi)與免疫: 主要(yao)關注和(he)揭示糖基化修(xiu)飾(shi)、糖苷(gan)和(he)凝集素(su)在感染、腫瘤免疫識(shi)別和(he)逃逸(yi)中的(de)關鍵功能(neng)。

2.感染免(mian)疫(yi): 人類(lei)重要病(bing)原(yuan)微(wei)生物(wu)(丙肝、結(jie)核(he)等)慢(man)性感染、致病(bing)及免(mian)疫(yi)逃逸機制(zhi)研(yan)究;設計(ji)和研(yan)制(zhi)了特異結(jie)合這些(xie)病(bing)原(yuan)微(wei)生物(wu)/腫(zhong)瘤細(xi)胞表面糖苷的藥物(wu)分子、糖基化(hua)抑制(zhi)劑、有效(xiao)診斷試劑和疫(yi)苗。












代表性論著:

1.Wang SR, Min YQ, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T, Zhang XL*, Zhou X*. (2016) A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target, Science Advances, 2(4): e1501535.

2.Sun X, Pan Q, Yuan C, Wang Q, Tang XL, Ding K, Zhou X, Zhang XL*. (2016) A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against Tuberculosis. J Am Chem Soc. 138(36):11680-9.

3.Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. (2014). Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 22(5):940-51.

4. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. (2014). Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 193(2):783-96.

5.Xiang T, Yang G, Liu X, Zhou Y, Fu Z, Lu F, Gu J, Taniguchi N, Tan Z, Chen X, Xie Y, Guan F, Zhang XL*. (2017) Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. Biochim Biophys Acta. 861(5 Pt A):1036-1045.

6.Yang YF, Zhou YD, Hu JC, Luo FL, Xie Y, Shen YY, Bian WX, Yin ZN, Li HL, Zhang XL*.(2017) FCN-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. Immunology Apr 5. doi: 10.1111/imm.12741.

7.Qian XJ#, Zhang XL#, Zhao P, Jin YS, Chen HS, Xu QQ, Ren H, Zhu SY, Tang HL, Zhu YZ, Qi ZT. (2016) A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. Sci Rep. 6:27268.

8.Tang XL, Wu SM, Xie Y, Song N, Guan Q, Yuan C, Zhou X, Zhang XL*. (2016) Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis. J Infect, 72(5):573-586.

9.Ren Y, Min YQ, Liu M, Chi L, Zhao P, Zhang XL*.(2016) N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses. Biochim Biophys Acta, 1860(8): 1764-1775.

10.Luo W, Qu ZL, Xie Y, Xiang J, Zhang XL*. (2015) Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent. J Infect, 71(5):534-543.

11.Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. (2014) CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect, 69: 569-580.

12.Tang XL, Yuan CH, Ding QQ, Zhou YD, Pan Q, Zhang XL*. (2017) Selection and identification of specific glycoproteins and glycan biomarkers of macrophages involved in Mycobacterium tuberculosis infection. Tuberculosis (Edinb), 104: 95-106.

13.Pan Q, Yan J, Liu Q, Yuan C, Zhang XL*. (2017) An ssDNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expression. Microbiol Immunol. 2017, 61: 92-102.

14.Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, Zhang XL*. (2016) Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin. 2016 Oct;31(5):406-414.

15.Chen T, Hu Y, Ding Q, Yu J, Wang F, Luo F, Zhang XL*. (2015) Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases. Virol Sin, 2015, 30(4):249-60.

16.Ding F, Guo S, Xie M, Luo W, Yuan C, Huang W, Zhou Y, Zhang XL*, and Zhou X*. (2015) Diagnostic applications of gastric carcinoma cell aptamers in vitro and in vivo. Talanta, 134:30-36.

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千亿体育